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Aussie scientists' breakthrough discovery about 'often misunderstood' condition

  • Researchers led by Carol Mathews reported the largest-ever genetic study of OCD on May 13 in Nature Genetics, analyzing over 53,000 OCD cases worldwide.
  • This study followed a two-decade collaboration involving genetic, psychiatric, and statistical experts who suspected OCD results from many genes rather than single causes.
  • They identified 30 genome regions containing 249 genes linked to OCD, many shared with depression, anorexia, and Tourette syndrome, showing complex genetic relationships.
  • Carol Mathews said, “we identified 30 regions,” emphasizing OCD involves circuits and hundreds of genes, not single genes or brain areas, which can aid understanding and treatment.
  • The findings could improve risk prediction, inspire drug repurposing, and highlight the need for funding to develop better diagnostics and interventions for this impairing condition.
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Sydney Morning HeraldSydney Morning Herald
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Aussie scientists' breakthrough discovery about 'often misunderstood' condition

Australian researchers have found the genes linked to obsessive compulsive disorder for the first time.

·Sydney, Australia
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UF Health, University of Florida Health broke the news in on Tuesday, May 13, 2025.
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