US EditionAI-Designed DNA Controls Genes in Healthy Mammalian Cells for First Time
- Scientists at the Barcelona Institute of Science and Technology's Centre for Genomic Regulation have published a study showing that AI-designed synthetic DNA sequences can precisely regulate gene activity in healthy mammalian cells.
- The team used generative AI to construct over 64,000 synthetic enhancers, aiming to decode and recreate DNA regulatory sequences governing blood cell development.
- The study revealed novel gene regulation principles, including negative synergy where combined factors repress genes despite activating them individually in distinct blood cell stages.
- Dr. Robert Frömel likened designing genetic sequences to "writing software but for biology," highlighting the precise control achievable over cellular behavior and gene activity.
- This advancement offers new tools for precise, cell-specific gene therapy, potentially improving treatment efficacy and reducing side effects by tailoring gene expression.
8 Articles
8 Articles
Science Daily
ecotopical.comAI-designed DNA controls genes in healthy mammalian cells for first time
A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. As a proof-of-concept, the authors of the study asked the AI to design synthetic fragments which activate a gene coding for a fluorescent protein in some cells while leaving gene expression patterns unaltered. They created the fragments from scratch and dropped them into mouse b…
A DNA devised with the help of artificial intelligence controls the behavior of mammalian cells for the first time
A team of scientists in Barcelona has created an artificial intelligence system capable of designing DNA fragments that control the functioning of healthy mammalian cells for the first time.
AI Designed DNA Sequences Modulate Cell Differentiation for Gene Therapy Applications
For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the differentiation process can lead to consequences, such as impaired tissue regeneration and the development of certain cancers. In a new study published in Cell titled, “Design principles of cell-state-specific enhancers in hematopoiesis,” researchers f…
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