US EditionOvary and fallopian tube removal linked to lower death risk in BRCA carriers with breast cancer
- On May 9, 2025, University of Cambridge researchers reported that breast cancer survivors with BRCA1 or BRCA2 variants who had bilateral salpingo-oophorectomy showed lower death risk.
- The study, using NHS data for over 3,400 women, examined the long-term impact of BSO amid prior concerns about menopause and potential health consequences.
- The analysis after nearly six years of follow-up found a 48% overall lower death risk among women who had BSO, with BRCA2 carriers seeing a 56% reduction and 40% lower second cancer risk.
- Lead researcher Hend Hassan stated the procedure brings clear survival benefits and fewer other cancers without increasing heart disease or depression, though a definitive causal link remains uncertain.
- These findings will aid counseling for women carrying BRCA variants, but Hassan noted some groups are less likely to undergo BSO, highlighting the need to understand and encourage its uptake.
26 Articles
26 Articles
Daily Journal
Ovary Removal Reduces Death, Cancer Risk Among Genetically Prone Breast Cancer Survivors
Key Takeaways
Removing ovaries and fallopian tubes linked to lower risk of early death among breast cancer patients with BRCA cancer genes
Women diagnosed with breast cancer who carry particular BRCA1 and BRCA2 genetic variants are offered surgery to remove the ovaries and fallopian tubes as this dramatically reduces their risk of ovarian cancer. Now, researchers have shown that this procedure -- known as bilateral salpingo-oophorectomy (BSO) -- is associated with a substantial reduction in the risk of early death among these women, without any serious side-effects.
Ovary and fallopian tube removal linked to lower death risk in BRCA carriers with breast cancer
Women diagnosed with breast cancer who carry particular BRCA1 and BRCA2 genetic variants are offered surgery to remove the ovaries and fallopian tubes as this dramatically reduces their risk of ovarian cancer.
Associations between Breast Reconstruction Surgery vs. Mastectomy without Reconstruction on Postsurgical Radiation Treatment Modalities: a 2004-2018 NCDB Study
Background This study compares associations between breast reconstruction surgery (BRS) and types of postmastectomy radiation treatment modalities for breast cancer.Methods Utilizing the NCDB Breast participant use file (PUF) from 2004–2018, we compared the post...
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