ESC085 Lipid sinks: statins, ezetimib and fibrates

In this episode, Hans-Dieter Höltje and Bernd Rupp talk about active ingredients for lowering cholesterol levels and triglyceride concentration in the blood. At the beginning, they explain the different transport forms of lipids in the blood as well as the biosynthesis of cholesterol in cells, especially in the liver. They address central intermediate products and their structural features in order to derive the points of attack of the most impo…