Two HIV Vaccine Trials Show Proof of Concept for Pathway to Broadly Neutralizing Antibodies

Two HIV vaccine trials show proof of concept for pathway to broadly neutralizing antibodies

A decades-long scientific challenge in HIV vaccine development has been finding a way to train the immune system to produce antibodies that can target many variants of the virus. Traditional approaches haven't worked -- largely because HIV mutates rapidly and hides key parts of itself from the immune system. Now, a new study combining data from two separate phase 1 clinical trials shows that a targeted vaccine strategy can successfully activate …

Early-stage HIV vaccine triggers targeted immune response in human trial

Worldwide, an estimated 40 million people live with HIV. Two-thirds of this group are on the African continent. In 2023, more than 600,000 people died from HIV-related causes and 1.32 million were infected. There is no vaccine against the world's second most deadly infection, after TB. However, researchers from Amsterdam UMC have set an important first step in reaching that goal. The results of their phase one trial are published in Science.

HIV Vaccine Trials Report Positive Results for Germline Targeting Strategy

Two studies published back to back in Science show early clinical promise for the development of HIV vaccines that can induce broadly neutralizing antibodies (bnAbs) against the virus, which is considered the holy grail for a preventive HIV vaccine. These studies represent a step forward in the prevention of one of the world’s most deadly infections, second only to tuberculosis.  No vaccine candidate against HIV has been successful in late-stage…

Every day, around 3,600 people worldwide are infected with the HIV virus. But there is hope on the horizon. Researchers at the Amsterdam UMC have taken an important step in the development of a vaccine. Their phase 1 study, the results of which were published this week in Science, shows that an innovative approach – the so-called […] More science? Read the latest articles on Scientias.nl .

Factors Associated with Quality of Life among People Living with HIV/AIDS in Mali, 2023

Introduction HIV is a source of concern, profoundly affecting the quality of life (QoL) of those affected. This study aimed to identify factors associated with the QoL of people living with HIV/AIDS (PLHIV) in Bamako in 2023.  Methods: A cro...