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FDA warns of ‘rare but severe itching’ after using popular allergy medications

  • The FDA issued a warning on May 16, 2025, about rare but severe itching after stopping popular allergy medications Zyrtec and Xyzal.
  • This warning followed reports from 209 cases of intense pruritus appearing days after ceasing daily use of these medicines for several weeks or longer.
  • Many patients experienced itching severe enough to disrupt daily life, requiring medical intervention, including hospitalization and disability.
  • The FDA advised individuals to consult their healthcare providers if they have any doubts or worries regarding the potential dangers of using these medications and has requested that pruritus warnings be included on the labels of Zyrtec and Xyzal.
  • Although the reaction is very rare given widespread use, the FDA cannot determine how likely itching occurs after stopping these antihistamines, so patient caution is advised.
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MedPage Today broke the news in New York, United States on Tuesday, May 20, 2025.
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