Caltech-Led Team Develops Ultrasound-Enabled 3D Printing Inside Living Bodies
- A Caltech-led team developed the imaging-guided DISP platform in 2025 to 3D print biomaterials inside living tissues using ultrasound guidance.
- This development addresses challenges in in vivo bioprinting including poor tissue penetration and limited bioink options by using focused ultrasound and temperature-sensitive liposomes.
- The team successfully demonstrated DISP by printing drug-laden biomaterials near mouse bladder tumors and within deep rabbit muscles, monitored in real-time with gas vesicle ultrasound contrast agents.
- Wei Gao highlighted that DISP technology is capable of fabricating diverse biomaterials suited for numerous applications, whereas Xiao Kuang emphasized that further development is required before the technology can be applied clinically.
- This ultrasound-guided 3D printing offers a noninvasive method for customized implants and therapies, potentially reducing surgical risks and improving recovery, though further research is essential.
8 Articles
8 Articles
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Health Rounds: Ultrasound triggers experimental 3D drug-delivery implants
(Reuters) – (This is an excerpt of the Health Rounds newsletter, where we present latest medical studies on Tuesdays and Thursdays) Ultrasound waves can penetrate through thick tissues and print medical implants inside a body, experiments in animals suggest. Researchers created 3D implants using focused ultrasound and ultrasound-responsive bioinks delivered via injection or catheter. The carefully guided ultrasound waves trigger localized heatin…
Caltech team 3D-prints drug depots inside living tissue
Caltech engineers have turned focused ultrasound into a noninvasive “printhead,” raising tissue temperature by only a few degrees to solidify injectable bio-inks several centimeters beneath the skin. The deep-tissue in-vivo sound-printing (DISP) technique shaped drug-loaded hydrogels next to mouse bladder tumors—killing more cancer cells than a direct doxorubicin shot—and built conductive gels inside rabbit muscle… The post Caltech team 3D-print…
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