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Caltech-Led Team Develops Ultrasound-Enabled 3D Printing Inside Living Bodies

  • A Caltech-led team developed the imaging-guided DISP platform in 2025 to 3D print biomaterials inside living tissues using ultrasound guidance.
  • This development addresses challenges in in vivo bioprinting including poor tissue penetration and limited bioink options by using focused ultrasound and temperature-sensitive liposomes.
  • The team successfully demonstrated DISP by printing drug-laden biomaterials near mouse bladder tumors and within deep rabbit muscles, monitored in real-time with gas vesicle ultrasound contrast agents.
  • Wei Gao highlighted that DISP technology is capable of fabricating diverse biomaterials suited for numerous applications, whereas Xiao Kuang emphasized that further development is required before the technology can be applied clinically.
  • This ultrasound-guided 3D printing offers a noninvasive method for customized implants and therapies, potentially reducing surgical risks and improving recovery, though further research is essential.
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Phys.org broke the news in United Kingdom on Thursday, May 8, 2025.
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