Genome-Wide Analyses Identify 25 Infertility Loci and Relationships with Reproductive Traits Across the Allele Frequency Spectrum

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female infertility. We additionally identify up to 269 genetic loci associated with follicle-stimulating hormone, luteinizing hormone, estradiol and testosterone through sex-specific GWAS meta-analyses (n = 6,095–246,…

IVF Can Challenge Relationships—Here's How You Can Overcome It

A new study highlights the impact fertility care can have on couples. Experts share ways to get through it.Fact checked by Sarah ScottParents/GettyImages/T-studios2 Couple holds hands at home.It probably won’t surprise anyone who has gone through in vitro fertilization (IVF) that a recent survey determined the true toll of fertility care extends far beyond finances. Indeed, while undergoing IVF involves a shocking price tag many are unprepared f…

Post-surgery recovery for women, what to know with endometriosis

DEAR MAYO CLINIC: I was recently diagnosed with advanced-stage endometriosis and I am told I need to have surgery. I still want children someday — should I be worried about my future fertility? What else should I know about recovering…

Scientists Discover Temperature-Controlled Switch That Powers Fertility

A mouse study may pave the way for new approaches to contraception and infertility treatment. Sperm are surprisingly picky when it comes to temperature. In mammals, including humans, they perform best in environments that are a few degrees cooler than normal body temperature. This raises an intriguing question: how do these heat-sensitive cells manage to [...]

Inflammation in reproductive tract linked to infertility, hormone therapy may help

Inflammation in the female reproductive tract may make it difficult to conceive a child, but replenishing a key hormone could keep inflammation in check, according to researchers from the University of Missouri School of Medicine.

Infertility and fertility treatment linked to cervical insufficiency risk

A study found that nulliparous women with infertility, especially those using fertility treatments, face increased odds of cervical insufficiency and related pregnancy complications.