US EditionJCI Bacterial vaginosis associates with dysfunctional T cells and altered soluble immune factors in the cervicovaginal tract
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JCI Bacterial vaginosis associates with dysfunctional T cells and altered soluble immune factors in the cervicovaginal tract
BACKGROUND Bacterial vaginosis (BV) is a dysbiosis of the vaginal microbiome that is prevalent among reproductive-age females worldwide. Adverse health outcomes associated with BV include an increased risk of sexually acquired HIV, yet the immunological mechanisms underlying this association are not well understood.METHODS To investigate BV-driven changes to cervicovaginal tract (CVT) and circulating T cell phenotypes, Kinga Study participants w…
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