US EditionExperimental drug could offer pain relief without the side effects of opioids
- Researchers at Duke University developed an experimental drug called SBI-810 to relieve pain without opioid side effects.
- The drug responds to urgent needs as overdose deaths, mostly from opioids, have increased since the 1990s despite a recent decline.
- SBI-810 targets neurotensin receptor 1 using biased agonism, activating pain relief without causing addiction or common opioid side effects like constipation.
- In mice, SBI-810 outperformed drugs like gabapentin and oliceridine by reducing pain from surgery, fractures, and nerve injury without sedation or memory problems.
- Still in early development, SBI-810 could offer a safer option for acute and chronic pain, potentially aiding those recovering from surgery or with diabetic nerve pain.
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The IndependentReposted by 
The Independent (US)
The Independent (US)An experimental painkiller could be the key to solving the opioid epidemic
The drug could offer powerful pain relief without the dangerous side effects of opioids
·London, United Kingdom
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Experimental painkiller could outsmart opioids -- without the high
A study shows a non-opioid pain reliever blocks pain at its source -- calming specific nerve signals that send pain messages to the brain. In mice, the compound SBI-810 eased pain from surgery, bone fractures, and nerve injury without causing sedation or constipation.
·United States
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