New technology maps molecules within single cells to uncover disease mechanisms

Single-Cell Genomics and Proteomics: Leading the Future of Biomedical Research

"Transforming Biological Research and Personalized Medicine: Single-Cell Genomics and Proteomics Show Cellular Heterogeneity, Driving Advances in Disease Mechanisms, Drug Discovery, and Precision Medicine"

Multimodal cell maps as a foundation for structural and functional genomics

Human cells consist of a complex hierarchy of components, many of which remain unexplored1,2. Here we construct a global map of human subcellular architecture through joint measurement of biophysical interactions and immunofluorescence images for over 5,100 proteins in U2OS osteosarcoma cells. Self-supervised multimodal data integration resolves 275 molecular assemblies spanning the range of 10−8 to 10−5 m, which we validate systematically using…

New technology maps molecules within single cells to uncover disease mechanisms

Tissues consist of a heterogenous mixture of different cell types, complicating our understanding of their biological functions and studies of disease.

Visualizing Intracellular Molecular Landscapes in Single Cells

The t-SPESI method enables real-time visualization of intracellular lipids, offering insights into disease mechanisms and improving diagnostic tool development.

Tissues consist of a heterogeneous mixture of different types of cells, complicating our understanding of their biological functions and disease studies. Now, a multi-institutional team led by the University of Osaka has developed and provided proof of the concept of a new technology to visualize the distribution of components within a single cell, opening [...]