Ovarian vascular aging: a hidden driver of mid-age female fertility decline

Ovarian vascular aging: a hidden driver of mid-age female fertility decline

Although ovarian reserve remains sufficient, ovarian function declines in mid-age, leading to reduced fertility around age 35, with the causes remaining unclear. Recent studies highlight vascular aging as a key factor in this decline, with age-related reductions in ovarian vascular remodeling disrupting oocyte development. Salidroside, a natural compound that reverses ovarian vascular aging and promotes ovarian angiogenesis, presents a promising…