Oral Norovirus Vaccine Candidate Successfully Tested in Human Challenge Trial

Oral norovirus vaccine candidate successfully tested in human challenge trial

Vaxart Inc., in collaboration with researchers from multiple academic institutions, evaluated the VXA-G1.1-NN vaccine against norovirus infection. Findings show a 30% reduction in infection rates among vaccinated participants compared to those receiving a placebo, along with reduced viral shedding and increased levels of protective antibodies in blood and mucosal tissues.

Symptoms of vomiting bug 'can appear between 12 days and eight hours later' - The Mirror

As the number of norovirus cases remain high, the public has been urged to avoid hospitals and care homes if experiencing symptoms

Norovirus vaccine pill protects against winter vomiting bug

An oral vaccine reduced infection risk in a trial where people were deliberately exposed to high doses of norovirus, and could also slow the spread of the pathogen

Norovirus is one of the leading causes of gastrointestinal infections worldwide. Now, an oral vaccine has managed to generate strong immune responses in the mucosa and even reduce the spread of the virus in vaccinated volunteers, reported EFE. It is the results of a phase 2 clinical trial driven by Vaxart, [...] The entry Oral Norovirus Vaccine gives positive results in a phase 2 clinical trial was first published in Information Focus.

Oral Norovirus Vaccine Generates Immunity, Reduces Viral Shedding in Phase II

Often dubbed the “perfect pathogen,” norovirus is a highly contagious virus responsible for acute gastroenteritis (AGE) outbreaks worldwide. It spreads through contaminated food, water, person-to-person contact, and even aerosolized particles. For vulnerable populations like children and older adults, infections frequently require hospitalization and intravenous rehydration. Despite its significant public health impact, an effective vaccine has …

Noroviruses are extremely contagious and cause severe gastrointestinal diseases. Current research indicates that everyday food may have a surprising protective effect.