Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease

Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease

The immune–epithelial–stromal interactions underpinning intestinal damage in celiac disease (CD) are incompletely understood. To address this, we performed single-cell transcriptomics (RNA sequencing; 86,442 immune, parenchymal and epithelial cells; 35 participants) and spatial transcriptomics (20 participants) on CD intestinal biopsy samples. Here we show that in CD, epithelial populations shifted toward a progenitor state, with interferon-driv…

'Rogue' immune cells explain why a gluten-free diet fails in some celiac patients

Researchers at the Garvan Institute of Medical Research and UNSW Sydney have discovered why some people with celiac disease continue to suffer debilitating symptoms despite strictly avoiding gluten.

Variations of interleukin (IL) 1 Beta (IL 1 β) and interferon gamma (INF-Ɣ) in Diabetic and Non-Diabetic Celiac Patients

Background Celiac disease (CD) is a chronic autoimmune disorder characterized by a noxious immune response to gluten in genetically susceptible persons. CD has a coincidence with diabetes mellitus, particularly type 1 diabetes, due to shared genetic risk factors and autoimmune mechani...

Celiac Disease and Type 1 Diabetes: What's the Connection? - Breakthrough T1D

People with type 1 diabetes (T1D) are at an increased risk of developing other autoimmune diseases, with celiac disease being the most common. In fact, nearly 10% of those with T1D also have celiac disease. Here, we explore what celiac disease is, how to treat it, and its connection to T1D. What is celiac disease? Celiac disease is an autoimmune condition in which a person’s body cannot digest foods that contain gluten, a protein found in wheat,…

16 May: A Wake-Up Call for the Hospitality Sector - CLH News: Caterer, Licensee and Hotelier News - News for Pubs, Bars, Hotels and Restaurants

Share Post Share Email Philip Rayner, Founder and MD of Glebe Farm Foods Every year, International Coeliac Disease Awareness Day on 16th May shines a light on a condition that affects millions yet remains widely misunderstood[1]. Coeliac disease is an autoimmune disorder triggered by gluten, a protein found in wheat, barley and rye. For those with the condition, ingesting even tiny traces of gluten can cause se…

‘Rogue’ immune cells explain why a gluten-free diet fails in some coel

‘Rogue’ immune cells explain why a gluten-free diet fails in some coeliac patients Scientists have identified mutated immune cell clones that could point to improved treatment for refractory coeliac disease. The discovery can also help explain why some people with coeliac disease continue