CAR-T cell therapy for cancer causes 'brain fog,' study shows
- A 2025 study from Stanford Medicine reveals that treatment with CAR-T cell immunotherapy can lead to subtle but lasting cognitive difficulties, often described as brain fog, in both cancer patients and mice.
- This finding arose from reports of cognitive complaints after immunotherapy and animal models that isolated immunotherapy as the cause of lasting cognitive symptoms.
- The study reveals that systemic immune activation induces chronic microglial inflammation, damaging oligodendrocytes and myelin, thus disrupting neural conduction and cognition.
- Researchers reversed cognitive deficits in mice by depleting and repopulating microglia and blocking chemokine receptor signaling, identifying promising therapeutic targets.
- These results prompt development of treatments addressing neuroinflammation to improve quality of life for cancer survivors experiencing brain fog after CAR-T therapy.
18 Articles
18 Articles
New Zealand promotes expensive cancer therapy while at the same time promoting one of the causes of cancer
New Zealand’s Stuff newspaper has been publishing a series of articles about using CAR T-cell therapy to treat lymphatic cancers. New Zealand has the highest rate of lymphoma in the world. In […] The post New Zealand promotes expensive cancer therapy while at the same time promoting one of the causes of cancer first appeared on The Expose.
CAR T-Cell Therapy for Relapsed/Refractory Follicular Lymphoma
(MedPage Today) -- When it comes to relapsed/refractory follicular lymphoma, chimeric antigen receptor (CAR) T-cell therapy has become a go-to treatment for some patients, with its high end durable response rates, and lengthy survival outcomes...
Survey shows majority of Americans unaware of innovative cancer treatment
BUFFALO, N.Y. — Roswell Park Comprehensive Cancer Center is at the forefront of a new approach to cancer treatment, called CAR T-cell therapy. The little known, but highly promising technology breakthrough makes it possible for your body to fight cancer, often without invasive surgery, offering patients new hope for the possibility of long-term remission. However, a new survey by Roswell Park Comprehensive Cancer Center of 1,021 adults in the U…
Promising results after CAR T-cell therapy for leukemia and lymphoma
Swedish cancer patients treated with CAR T-cell therapy show better survival rates and fewer side effects than seen in previous studies. This is shown in a new compilation of Swedish treatment results conducted by researchers in the SWECARNET network.
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