SARS-CoV-2 Induced Immune Perturbations in Infants Vary with Disease Severity and Differ From Adults’ Responses

SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults’ responses

Differences in immune profiles of children and adults with COVID-19 have been previously described. However, no systematic studies have been reported from infants hospitalized with severe disease. We applied a multidimensional approach to decipher the immune responses of SARS-CoV-2 infected infants (n = 26; 10 subacute, 11 moderate and 5 severe disease; median age = 1.6 months) and matched controls (n = 14; median age = 2 months). Single cell (s…

Study shows infant immune systems respond differently to severe COVID-19

Infants hospitalized with severe COVID-19 have significantly different immune responses than adults or older children. The finding comes from scientists at St. Jude Children's Research Hospital, The Jackson Laboratory for Genomic Medicine, Weill Cornell Medicine, Nationwide Children's Hospital, Icahn School of Medicine at Mt. Sinai and Yale University.

Infant Immune Systems Respond Differently to Severe COVID-19

A St. Jude-led collaboration characterized the unique features of hospitalized infants’ immune response to SARS-CoV-2, the virus that causes COVID-19.