Twin Pair Analysis Uncovers Links Between DNA Methylation, Mitochondrial DNA Quantity and Obesity

Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity

Alterations in mitochondrial metabolism in obesity may indicate disrupted communication between mitochondria and nucleus, and DNA methylation may influence this interplay. Here, we leverage data from the Finnish Twin Cohort study subcohort (n = 173; 86 full twin pairs, 1 singleton), including comprehensive measurements of obesity-related outcomes, mitochondrial DNA quantity and nuclear DNA methylation levels in adipose and muscle tissue, to iden…

Twin study sheds light on how mitochondria influence the gene regulation behind obesity

Mitochondria play a central role in energy metabolism and overall health. In obesity and its comorbidities, mitochondrial activity is often impaired, yet it has remained unclear whether this impairment increases the risk of obesity or whether obesity itself damages mitochondria.

New study finds the key to fighting obesity and diabetes

Scientists at Sweden’s Karolinska Institutet have discovered a promising new way to tackle obesity and its related conditions like fatty liver disease and type 2 diabetes. Their study, published in Nature Metabolism, suggests that targeting mitochondria—the tiny energy producers inside our cells—could help combat these widespread health issues. Mitochondria are often called the “powerhouses” of cells […] The post New study finds the key to fight…