Vaccine developed in Nebraska could signal end to annual flu shot
- Eric Weaver's laboratory at the University of Nebraska-Lincoln developed a vaccine in 2025 that protects against H1 and H3 influenza strains in swine and aims for human application.
- The vaccine follows an analysis of over 6,000 influenza virus strains from 1930 to 2021 using Epigraph software to target common viral epitopes for broad immunity.
- Swine vaccinated with the Epigraph vaccine showed strong antibody and T-cell responses lasting six months, outperforming current commercial and wild type vaccines against multiple strains.
- Weaver emphasized that stopping influenza infections in pigs could halt the transmission of the virus from animals to humans, with the broader aim of ultimately eradicating influenza and greatly lessening its impact.
- The findings pave the way for developing universal influenza vaccines that could eliminate the need for yearly flu shots, although collaboration with a biotech company and additional human trials are needed to verify their effectiveness.
15 Articles
15 Articles

Trump administration's universal flu vaccine project puzzles scientists
The Trump administration has launched a $500 million project to develop a universal flu vaccine that won't need yearly updates. But vaccine experts are mystified by its focus on a dated technology.
Vaccine For All Influenza A strains Developed In Nebraska
A new vaccine that will allegedly protect against several strains of influenza A viruses has been developed in Nebraska. This is one shot for the avian influenza (bird flu), swine flu, and the seasonal flu, all wrapped up in one injection. This new vaccine strategy was developed and tested by a team from the University of Nebraska-Lincoln and could signal an end to the annual flu shot routine. Instead, you can get three vaccines in one shot. “Th…

Vaccine developed in Nebraska could signal end to annual flu shot
LINCOLN — A new vaccine strategy developed and tested by a team from the University of Nebraska-Lincoln could signal an end to the annual flu shot routine. The possible breakthrough is laid out in newly published research in Nature Communications.…
Trump administration's universal flu vaccine project puzzles scientists - TPR: The Public's Radio
The Trump administration has launched a $500 million project to develop a universal flu vaccine that won't need yearly updates. But vaccine experts are mystified by its focus on a dated technology. The post Trump administration’s universal flu vaccine project puzzles scientists appeared first on TPR: The Public's Radio.
New vaccine to protect against swine, human and bird flu; ward off annual shots - IndiaPost NewsPaper
NEW DELHI: US researchers have developed a novel vaccine that protects against H1N1 swine flu and can also protect against influenza in humans and birds. The vaccine strategy developed and tested by researchers at the University of Nebraska-Lincoln in the US can also eliminate the need for annual flu shots. “This research sets the stage for developing universal influenza vaccines, so people won’t have to go to the doctor and get a flu shot every…
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