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Vaccine developed in Nebraska could signal end to annual flu shot

  • Eric Weaver's laboratory at the University of Nebraska-Lincoln developed a vaccine in 2025 that protects against H1 and H3 influenza strains in swine and aims for human application.
  • The vaccine follows an analysis of over 6,000 influenza virus strains from 1930 to 2021 using Epigraph software to target common viral epitopes for broad immunity.
  • Swine vaccinated with the Epigraph vaccine showed strong antibody and T-cell responses lasting six months, outperforming current commercial and wild type vaccines against multiple strains.
  • Weaver emphasized that stopping influenza infections in pigs could halt the transmission of the virus from animals to humans, with the broader aim of ultimately eradicating influenza and greatly lessening its impact.
  • The findings pave the way for developing universal influenza vaccines that could eliminate the need for yearly flu shots, although collaboration with a biotech company and additional human trials are needed to verify their effectiveness.
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nationalhogfarmer.com broke the news in on Monday, May 12, 2025.
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