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Genetic Mutation Behind Orange Cat Fur Identified in Breakthrough Studies

  • Researchers have discovered a DNA deletion responsible for the orange coat color in domestic cats, as detailed in a pair of studies released in Current Biology in mid-May.
  • Researchers investigated this because the orange fur trait resides on the X chromosome and mostly occurs in male cats.
  • Analyzing DNA from about 30 cats, teams found a deletion near Arhgap36 that increases its protein in pigment cells, reducing darker pigments.
  • All 258 orange cats in a global database had this deletion while non-orange cats lacked it, confirming its role in ginger fur.
  • The mutation likely originated over 900 years ago in one ancestral cat and is unique to domestic felines' ginger coloring.
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The Telegraph broke the news in London, United Kingdom on Thursday, May 15, 2025.
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