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Rare genetic mutation lets some people thrive on just 4 hours of shut-eye

  • In May 2025, a research team led by scientists in China discovered a rare SIK3-N783Y gene mutation associated with shorter sleep duration in a healthy woman in her seventies.
  • This discovery builds on prior findings that genetic factors influence sleep duration and that four genes previously linked to natural short sleep now include SIK3 as a fifth.
  • The mutation enabled the woman and genetically engineered mice to sleep less—mice reduced sleep by about 31 minutes compared to their usual 12 hours.
  • The researchers explained that their results deepen insights into the genetic factors influencing sleep and identify SIK3 as a valuable target for developing treatments aimed at sleep disorders.
  • This study supports the concept that some people naturally function well on four to six hours of sleep, highlighting genetic influences on sleep efficiency and potential therapies.
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geo broke the news in on Tuesday, May 6, 2025.
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